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Tetracycline Hydrochloride is a broad-spectrum antibiotic derived from Streptomyces aureofaciens.

Tetracycline Hydrochloride – Laboratory Grade

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Tetracycline Hydrochloride – Laboratory Grade

AuSaMicS Life Science™ | www.ausamics.com.au

Product Description
Cat. No. ASA-2022
For Laboratory Use Only
CAS Number
64-75-5
Purity
≥98%
Molar Mass
480.90 g/mol
HS Code
29413000
Description

Tetracycline Hydrochloride is a broad-spectrum antibiotic derived from Streptomyces aureofaciens. It inhibits protein synthesis in bacteria by binding to the 30S ribosomal subunit and preventing the attachment of aminoacyl-tRNA. Due to its well-characterized mechanism of action and effectiveness against a variety of Gram-positive and Gram-negative bacteria, it is a valuable tool in microbiological, molecular, and biochemical research.

This laboratory-grade material is supplied as a yellow crystalline powder with high purity and excellent aqueous solubility. It is commonly used as a selective agent in microbiological media, tetracycline-regulated gene expression systems, and antibiotic mode-of-action studies.

Key Features & Benefits
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Broad-Spectrum Activity Useful against a wide range of Gram-positive and Gram-negative bacteria in laboratory studies.
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Gene Regulation Utility Suitable as a selective agent in tetracycline-regulated molecular biology systems.
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High Water Solubility Freely soluble in water for convenient stock solution preparation and media supplementation.
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Cold Storage Recommended Store at 2–8°C, tightly sealed and protected from light and moisture for optimal stability.
Applications
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Microbiology
  • Antimicrobial susceptibility testing
  • Evaluation of bacterial resistance in laboratory strains
  • Selective microbiological media supplementation
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Molecular Biology
  • Selective agent in tetracycline-regulated gene expression systems
  • Plasmid maintenance and regulated promoter studies
  • Research involving inducible expression systems
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Research Studies
  • Pharmacological studies of antibiotic action
  • Veterinary and agricultural research in controlled settings
  • Biochemical studies on bacterial protein synthesis inhibition
Physical & Technical Properties
Catalog NumberASA-2022 CAS Number64-75-5 Chemical FormulaC₂₂H₂₄N₂O₈·HCl Molar Mass480.90 g/mol Purity≥98% FormYellow crystalline powder SolubilityFreely soluble in water; slightly soluble in ethanol pH (1% solution)2.0–3.0 Storage ConditionsStore at 2–8°C, tightly sealed, protected from light and moisture Shelf Life2 years from date of manufacture (when stored as recommended) Pack Sizes Available5 g, 10 g, 25 g, 50 g (custom quantities available on request) HS Code29413000 Country of OriginAustralia
⚠ Safety & Handling May cause skin or eye irritation. Harmful if swallowed or inhaled. Use in a fume hood or well-ventilated area. Wear appropriate PPE. For laboratory research use only. Not for human or veterinary use.
Disclaimer AuSaMicS Pty Ltd supplies this product for laboratory research use only. No warranty is made regarding fitness for diagnostic, therapeutic, veterinary, food, or household use. End users are responsible for determining suitability and compliance with all applicable regulations for storage, handling, use, and disposal.

Safety Data Sheet

Tetracycline Hydrochloride – Laboratory Grade | Cat. ASA-2022

SDS — GHS Format
SDS-ASA-2022 | Rev. 1.0
Issue Date: March 2026
Section 1 — Identification
Product NameTetracycline Hydrochloride – Laboratory Grade Catalog No.ASA-2022 CAS No.64-75-5 Chemical FormulaC₂₂H₂₄N₂O₈·HCl Recommended UseLaboratory antibiotic reagent; microbiological, molecular, and biochemical research SupplierAuSaMicS Pty Ltd, Melbourne, Australia Emergency Contact+61 412 520 598 | support@ausamics.com Emergency ServicesAustralia: 000 | Poisons Information Centre: 13 11 26
Section 2 — Hazard Identification
GHS Classification: Harmful if swallowed or inhaled. May cause skin or eye irritation. Dust may irritate the respiratory tract.
Signal WordWarning Hazard StatementsH302 — Harmful if swallowed. H332 — Harmful if inhaled. H315 — Causes skin irritation. H319 — Causes serious eye irritation. Precautionary StatementsP261 — Avoid breathing dust. P264 — Wash thoroughly after handling. P270 — Do not eat, drink or smoke when using this product. P280 — Wear protective gloves, protective clothing and eye protection. Regulatory StatusFor laboratory research use only. Not for human or veterinary use.
Section 3 — Composition / Ingredients
Component CAS Number Nature Content
Tetracycline Hydrochloride 64-75-5 Active antibiotic substance ≥98%
Residual impurities / moisture Minor residual components ≤2%
Section 4 — First Aid Measures
Skin ContactWash immediately with plenty of soap and water. Remove contaminated clothing. Seek medical advice if irritation persists. Eye ContactRinse cautiously with water for at least 15 minutes. Remove contact lenses if present and easy to do. Seek medical attention if irritation persists. InhalationMove affected person to fresh air. Seek medical attention if symptoms persist. IngestionRinse mouth with water. Do not induce vomiting unless directed by medical personnel. Contact a doctor or Poisons Information Centre if unwell.
Section 5 — Fire-Fighting Measures
Suitable Extinguishing MediaWater spray, foam, dry powder, or carbon dioxide Specific HazardsThermal decomposition may produce carbon oxides, nitrogen oxides, and hydrogen chloride fumes Protective EquipmentFirefighters should wear full protective clothing and self-contained breathing apparatus (SCBA)
Section 6 — Accidental Release Measures
Personal PrecautionsAvoid dust formation. Wear gloves, protective clothing, eye protection, and respiratory protection where needed. Environmental PrecautionsPrevent release to drains, waterways, and the environment. Antibiotic residues should not be discharged uncontrolled. Clean-Up MethodsCarefully sweep or vacuum into a suitable sealed container. Avoid generating dust. Clean residue with damp absorbent material.
Section 7 — Handling & Storage
HandlingUse in a fume hood or well-ventilated area. Avoid inhalation of dust and contact with skin or eyes. Storage ConditionsStore at 2–8°C, tightly sealed, protected from light and moisture IncompatibilitiesStrong oxidising agents, strong alkalis, and prolonged exposure to heat and light Shelf Life2 years from manufacture date under recommended conditions
Section 8 — Exposure Controls / PPE
Control Measure Recommendation
Occupational Exposure Limit No specific exposure limit established; minimise dust exposure
Respiratory Protection Dust mask or particulate respirator when handling powder or where ventilation is inadequate
Hand Protection Nitrile or chemical-resistant gloves
Eye Protection Safety glasses or splash goggles
Body Protection Laboratory coat and appropriate protective clothing
Engineering Controls Use in fume hood or well-ventilated area
Sections 9–16 — Physical, Stability, Toxicology, Ecology, Disposal, Transport, Regulatory
AppearanceYellow crystalline powder SolubilityFreely soluble in water; slightly soluble in ethanol pH (1% solution)2.0–3.0 StabilityStable when stored cold, dry, and protected from light; may degrade under heat or prolonged light exposure ToxicologyHarmful if swallowed or inhaled; may cause irritation to skin, eyes, and respiratory tract EcologyAvoid environmental release; antibiotics may affect microbial populations in the environment DisposalDispose via licensed chemical waste contractor in accordance with local regulations TransportHandle as laboratory chemical; confirm shipping classification if transporting in bulk HS Code29413000 Prepared ByAuSaMicS Pty Ltd — Quality & Regulatory Affairs
Disclaimer This SDS-style section is provided in website format and should be reviewed against your approved regulatory SDS before release or publication.

Certificate of Analysis

Tetracycline Hydrochloride – Laboratory Grade | Cat. ASA-2022

COA — Batch Specific
COA-ASA-2022-L001
Issue Date: March 2026
Product Information
Product NameTetracycline Hydrochloride – Laboratory Grade Catalog No.ASA-2022 CAS No.64-75-5 Chemical FormulaC₂₂H₂₄N₂O₈·HCl Molar Mass480.90 g/mol GradeLaboratory Grade
Lot / Batch Information
Lot NumberASA2022-L001 Manufacture DateMarch 2026 Expiry DateMarch 2028 Pack Size5 g / 10 g / 25 g / 50 g Storage2–8°C, protected from light and moisture Country of OriginAustralia
Analytical Test Results
No. Test / Criteria Method Specification / Limit Result Status
1 Appearance Visual inspection Yellow crystalline powder Conforms PASS
2 Identity Reference standard / IR or HPLC Conforms to Tetracycline Hydrochloride Conforms PASS
3 Purity / Assay HPLC / validated assay ≥98.0% 98.6% PASS
4 Solubility Solubility test Freely soluble in water; slightly soluble in ethanol Conforms PASS
5 pH (1% solution) Potentiometry 2.0–3.0 2.5 PASS
6 Moisture / Loss on Drying Gravimetric Conforms to internal specification Conforms PASS
Overall Batch Disposition
RELEASED — COMPLIES WITH SPECIFICATIONS
Authorisation
Analysed By
QC Analyst | AuSaMicS Pty Ltd
Date: _______________
Approved & Released By
Quality Manager | AuSaMicS Pty Ltd
Date: _______________
Disclaimer This Certificate of Analysis applies only to the lot identified above and represents results obtained from a representative sample of the batch. This material is supplied for laboratory research use only.

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