Polymyxin B Sulfate Powder
Catalog Number: AS-2034
CAS Number: 1405-20-5
MW: 1301.56 g/mol
MF: C56H98N16O13.H2SO4
Polymyxin B Sulfate Powder actively disrupts cell membrane permeability by binding to it. Bacteria lacking sensitivity to Polymyxin B Sulfate possess cell walls that block its access to the cell membrane. This antibiotic lacks efficacy against gram-positive bacteria and Polymyxin B sulfate powder binds to the cell membrane thereby removing its permeability.
Bacteria that are not sensitive to polymyxin B sulfate have a cell wall that prevents polymyxin from reaching the cell membrane. This antibiotic does not affect the gram-positive bacteria, nor does it affect anaerobes. It does affect the gram-negative bacteria including the non-fermentative and Enterobacteriaceae strains.
The mechanism of action of this antibiotic is that polymyxin B sulfate binds to the lipopolysaccharides in the outer membrane of gram-negative bacteria. This binding destroys the cell membrane integrity leads to leakage of intracellular content out and death of bacteria. In clinical practice, polymyxin B sulfate is usually used as the last resort against multidrug-resistant infections. This antibiotic has activity against nosocomial infections caused by Pseudomonas aeruginosa and Acinetobacter baumannii.
For Laboratory Use Only Not for Human or Animal Usage
Polymyxin B Sulfate Powder
Cat. Number AS-2034 CAS Number 1405-20-5 MDL Number MFCD00131991 Pubchem 310279122 Molecular Weight 1301.56 g/mol Molecular Formula C56H98N16O13.H2SO4 Storage Temperature +4 °C Form and Color Powder / White to off-white Assay ≥ 6000 IU/mg Heavy Metals ≤ 20 ppm Specific Optical Rotation [α]D -90 to -78 FT-IR Spectrum Corresponds to reference spectrum Loss on Drying ≤ 7% pH Value 5 – 7.5 Synonym Mastimyxin / Aerosporin
